This section covers the ingredients found in Inflame & Pain Relief™ and discusses WHY & HOW they work, including links to clinical studies. You can also see "recommended use" instructions.
Below you'll find "Supplement Facts" and "Ingredient Summaries"
|Ingredients||Amount Per Serving||%DV*|
|IPR Synergy Optimizer™ Blend||3000 MG||†|
|Turmeric/Curcumin (95% Extract, Tetrahydrocurcuminoids)
(Blend of Curcumin C3 Complex® / C3 Reduct® / BCM-95® Bio-Curcumin®)
|Ginger Extract (Orgainc; 5% gingerols)||200 MG|
|AprèsFlex® Boswellia Serrata (65% extract)||240 MG|
|Green Tea Extract (Theaflavin) (98% poly, 50% EGCG)||400 MG|
|White Willow Bark (salicin) 25% salicylic acid||200 MG|
|Pine Bark Extract (Pinus massoniana) [97% Proanthocyanidins]||200 MG|
|Astragin® Astragalus||100 MG|
|Trans-Resveratrol (50% Extract; Japanese knotweed)||280 MG|
|Uncaria Tomentosa (cat's claw; 10:1 concentration; 2.3% pentacyclic oxindole alkaloids)||100 MG|
|Quercetin Phytosome||200 MG|
|PARACTIN® Andrographis 10:1||280 MG|
The Inflame & Pain Relief™ formula works so well and is popular because of the specific ingredients used in the correct combinations, dosages and extracts; resulting in maximum results & benefits. Click the ingredients below and a detailed description will appear under it.
Curcumin is the amazing active compound that is found within the turmeric root. It may be one of the most unique nutritional supplements in existence, IF you take the correct, absorbable form (more on that in a minute).
As great as these benefits are, the biggest problem with Turmeric/Curcumin is that it's poorly absorbed.
Which means, if you don't utilize the correct form and dose, you won't get the positive benefits and you'll just be wasting time and money.
Almost all Curcumin extracts (even those with a minimum 95% extract) are only 50% absorbed. So you'll have to take more than double the amount to get the optimal benefits.
This is why we've utilized the 3 most potent and highest absorbable Curcumin extracts - Patented & Scientifically Proven.
Curcumin C3 Reduct® (standardized min 95% tetra-hydro curcuminoids ) - One of the most active forms of Curcumin with 95% tetra-hydro curcuminoids, which is pre-converted and goes to work immediately.
Curcumin C3 Complex® (standardized min 95% total curcuminoids) - Is a patented and scientifically evaluated “Bioprotectant” composition of three Curcuminoids [Curcumin, Demethoxycurcumin (DMC) and Bisdemethoxycurcumin (BDMC)]. It's the most studied and validated Curcumin extract on the market. This is more of a slow-release form, over 12 hours.
BCM-95® Bio-Curcumin® - Is validated to have a 97% absorption rate and almost 9x higher bioavailability in the blood.. The end result is high blood concentrations, in less time. Thus, the positive effects are felt faster at an even lower dose, extended over 8 hours.
Ginger contains numerous beneficial compounds, including gingerols, which have free-radical scavenging and healthy inflammatory supporting properties.17*
Leukotrienes contribute to dangerous inflammatory reactions. Specific compounds in ginger have been found to help inhibit enzymes that produce leukotrienes.18,19*
Ginger also works to help reduce inflammation by affecting several other compounds and cellular pathways, including*:
One of the problems with aging is higher levels of 5-LOX. 5-lipoxygenase (5-LOX) is a member of the lipoxygenase family of enzymes. Excess levels of the enzyme 5-LOX cause inflammatory responses that have been linked to common effects in aging individuals (such as joint pain).*
Unfortunately, the typical diet most people eat these days, causes an over production of the 5-LOX enzyme. This further increases pro-inflammatory compounds, which attacks the:
Used for centuries to help with inflammatory factors, Boswellia supports and acts as a natural 5-LOX reducer, intervening at the cellular level to minimize its unwanted negative effects.*
Clinical studies reveal that a compound contained in Boswellia called AKBA (3-O-acetyl-11-keto-ß-boswellic acid)23,24 may be the key to its beneficial action.*
Green tea extract has numerous health benefits, one of them being the powerful anti-inflammatory effects due to the Theaflavin, polyphenols and EGCG.*
White willow bark is known as "nature's aspirin" and has been used for centuries as a pain reliever and anti-inflammatory.26* The active ingredient that causes the benefits of willow bark is salicin.
Inflame & Pain Relief™ uses the highest extract, at 25% salicylic acid. This means a lower dose is required, but resulting in more positive benefits.*
Pine bark extract has numerous health benefits:
The cushioning cartilage in your joints become damaged through wear and tear, which can cause inflammation and pain.* This can happen even faster for those that exercise.
Pine bark extract can ease these symptoms as it is:
Astragin® is a patented form of Astragalus, with over 25 clinical studies. Astragalus is from one of the most powerful immune-building plants on the planet.*
It's an "adaptogen", which means it activates when you're under stress to help promote lower cortisol levels, to help reduce inflammation.* Additionally, it helps increase the absorption of other nutrients by 92%. 32
Astragalus works by suppressing NF-kB and AP-1 signaling pathways, which is linked to inflammation.*
Best known as a compound found in red grapes and red wine, resveratrol helps promote and maintain optimal health and longevity.34 Inflame & Pain Relief™ contains trans-resveratrol, the form most abundant in red wine, which is well-absorbed and stable.35,36
Aside from its indirect antioxidant effects on inflammation, resveratrol also affects very specific inflammatory processes.*
For one, it can help reduce inflammatory COX enzymes, which are also the main target of commonly used painkillers and anti-inflammatory drugs.40*
However, its effects run much deeper than these conventionally targeted enzymes. Resveratrol also helps support the reduction of key anti-inflammatory factors:*
Quercetin is a bioflavonoid that supports healthy immune function and optimal inflammatory response.46,47*
One of the primary ways quercetin works, is by helping support a reduction of important inflammatory substances and pathways (including COX-2 and CRP), similar to drugs (but without the negatives).*
It also helps reduce the production of prostaglandins, one of the key mediators of the inflammatory response.48,49*
Cat’s claw is rich in three major groups of chemical compounds: alkaloids, terpenoids, and flavonoids. It works by supporting and:
ParActin™ is a patented standardized natural extract of Andrographis Paniculata, scientifically shown to help promote healthy inflammatory response and support healthy brain and joint function by naturally invigorating the PPAR gamma receptor, reducing pro-inflammatory cytokines that cause pain and redness from everyday activities.*
We've used a patented blend of these andrographolides because they help suppress damaging inflammatory cytokines and eases symptomatic discomfort associated with joint pain, stiffness and swelling.60-62*